Renal response to acid load after phenformin.
نویسندگان
چکیده
Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.
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عنوان ژورنال:
- British medical journal
دوره 4 5887 شماره
صفحات -
تاریخ انتشار 1973